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Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects

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The top portion in each of the six service lines is shaded and is the location for reporting supplemental information

Besouw MT, van Pelt AM, Gaide Chevronnay HP, Courtoy PJ, Pastore A, Goossens E, Devuyst O, Antignac C, Levtchenko EN (2012) Studying nonobstructive azoospermia in cystinosis: histologic examination of testes and epididymis and sperm analysis in a Ctns(-)/(-) mouse model

However, this therapy does not lower the levels of the intermediate metabolite, GAA, seen with GAMT deficiency

Proteinprotein interactions The context-dependent activation and inactivation of transcription co-activator function is often determined by the proteins they interact with